The 2019 Global Humanitarian Overview estimated over 132 million people in need though only 94 million can be targeted. Globally, the number, scale and severity of humanitarian crises exceed the current capacity of the international humanitarian system to deliver. There have been well-documented failures of the humanitarian health sector’s response to recent crises. At the same time, efforts to achieve universal health coverage are being significantly undermined by widespread corruption in frontline healthcare service delivery. Based on a review of the recent literature, we aimed to identify the main challenges that humanitarian supply-chain actors face in the global health sector. We explored how lack of traceability, accountability and visibility hinder the effectiveness of Non-Gouvernemantal Organisations (NGOs) activities in helping people in need and undermine the trust of donors.